News & Insight

News
Global team uncovers genomic secrets behind varied incidence in kidney cancer rates
Gary Hornett in sequencing laboratory, working at Illumina NovaSeq 600 machines
In a landmark paper published today (1 May, 2024) by the Mutographs team in Nature, they identify new mutational signatures at play in the development of clear cell renal cell carcinoma, of unknown origin, which contribute towards…
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Five new teams selected to take on cancer’s toughest challenges
Today we’re excited to announce the five new global teams that have been selected to each receive up to $25m in Cancer Grand Challenges funding over…
Blog
Embedding patient advocacy within a discovery science initiative
As we look towards announcing our new teams on 6 March, we reflect with former members of the Cancer Grand Challenges Advocacy Panel on the role the…
Blog
A holistic approach to cancer research: bringing future research leaders together with patient advocates
Last month we held our annual Future Leaders Conference in Lisbon. As well as being a time for early career researchers from across our funded teams…
News
Changing the narrative around ductal carcinoma in situ and breast cancer risk
New findings from the Cancer Grand Challenges PRECISION team this Breast Cancer Awareness Month show that breast cancer development from DCIS is a…

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Introducing the new members of the Cancer Grand Challenges Advocacy Panel
People
Introducing the new members of the Cancer Grand Challenges Advocacy Panel
We are pleased to welcome seven new members to the Cancer Grand Challenges Advocacy Panel: Yelak Biru, Ivana Cattaneo, Anjee Davies, Joya Harris, Dirk Hellrung, Chris Stewart and Christine Wu. From helping to shape…
New findings from the team taking on our Cachexia challenge
News
Considering the bigger picture in the treatment of cancer: new findings from the team taking on our Cachexia challenge
New research from the Cancer Grand Challenges CANCAN team finds that a ketogenic diet slows tumour growth but shortens survival by accelerating the onset of cancer cachexia in murine models. The findings, published in…
Exploring the crystallographic and chemical features of DCIS microcalcifications
News
Could microcalcification crystallography help to predict which DCIS cases might progress to invasive breast cancer?
New research from the Cancer Grand Challenges PRECISION team, published in Scientific Reports, finds that the crystallographic and chemical features of microcalcifications present in ductal carcinoma in situ (DCIS)…
Colour-enhanced microscopy image of a breast cancer cell.
News
Researchers identify new mechanism of oncogene amplification in breast cancer
A new Nature paper from the Cancer Grand Challenges SPECIFICANCER team describes a mechanism through which oestrogen-induced DNA breaks and their repair by inter-chromosomal translocations initiate a cascade of events…
Text that says pre application webinar recording
Video
Pre-application webinar: everything you need to know about applying
In March 2023, we launched nine new challenges, with up to £20m funding for global research teams. This webinar features everything you need to know about the Cancer Grand Challenges application process Hosted by…
Nine new Cancer Grand Challenges - challenge videos
Video
Nine new challenges videos
Members of our Scientific Committee discuss each of our nine new challenges, their potential impact and what we're looking for from applications Ageing and cancer Cancer cell plasticity  Cancer inequities…
David Scott and Dinah Singer
Coverage
AACR Cancer Discovery In Focus: harnessing the power of discovery
In an ‘In Focus’ commentary article for AACR Cancer Discovery, Dr David Scott and Dr Dinah Singer discuss our nine new Cancer Grand Challenges, for which Expressions of Interest are open until 22 June 2023. In March at…
Image of Stefan Hutten alongside the article title - A unique resource for studying DCIS and progression to cancer
News
A unique resource for studying DCIS and progression to cancer
Members of the Cancer Grand Challenges PRECISION team have developed a living biobank of 115 patient-derived Mouse-INtraDuctal (MIND) ductal carcinoma in situ (DCIS) models and used them to identify risk factors…
"NexTGen represents crucial and overdue work” Sara Wakeling, NexTGen team advocate and CEO and co-founder of Alice's Arc
News
Targeting vulnerabilities of childhood cancers
Cancer is the second leading cause of death among children and adolescents worldwide. Yet, despite progress in understanding the biology of many childhood cancers, treatments, particularly for solid tumours, have…