Early-onset colorectal cancer (EOCRC), also called young-onset colorectal cancer, is defined as CRC diagnosed in individuals aged less than 50 years. EOCRC is increasing globally and anticipated to become the leading cause of cancer death in individuals aged 20 to 49 in the US by 2030 (1). Since the 1990s, the age-adjusted incidence of EOCRC has risen at an alarming rate of 2 to 4% per year in many countries, with even sharper increases in individuals younger than 30 years (1). This is despite a reduction in overall CRC incidence that is likely attributable to improved screening and prevention in older individuals. The exact reasons and pathophysiology behind the rising incidence of EOCRC remain unknown. Currently, only limited studies exist and they have focused on single aspects of EOCRC etiology. A multidisciplinary path forward is needed to expand the understanding of this increasingly prevalent problem.