Professor Stephen Elledge
Meet Stephen, Team Lead of SPECIFICANCER and co-investigator on MATCHMAKERS
Professor Stephen Elledge is the Gregor Mendel Professor of Genetics and Medicine at Harvard Medical School. He has a long-standing interest in understanding the basis of genomic instability in cancer through cell cycle and DNA damage studies.
Along with Dr. Wade Harper, he discovered the two largest families of E3 ubiquitin ligases, the CRL family initiating with the Skp1-Cul1-F-box E3 ligase family, and the role of RING domain E3 ligases. Dr. Elledge has developed a number of genetic technologies in mammalian systems to probe the adaptive immune response in B and T cells such as VirScan that allow the virome-wide detection of antiviral antibodies from a single drop of blood to determine the history of viral exposure; T-Scan and TCR-MAP to identify the targets of TCRs to identify epitopes on cancer cells.
Dr. Elledge’s research has been recognined by a number of awards including election to the National Academy of Sciences, National Academy of Medicine, and the Breakthrough Prize in Life Sciences, The Gruber Prize in Genetics, and the Albert Lasker Basic Medical Research Award.